Cell Therapies 

Cells are the building blocks of life, and when living cells of a specific type are transplanted, they have the potential to treat or cure a wide variety of diseases and ailments.  Current common cell therapies include bone marrow transplants and stem cell treatments.

The Kanslet™ transplantation system is a simple procedure that transplants engineered cell clusters via injection to free pets of a specific disease and improve the quality of life for them and their owners. Using its patented 3D micromold system, Likarda can produce scaffold-free, uniform cell clusters in a high efficiency and scalable manner. Many cells prefer to be in a three-dimensional format as they better mimic and maintain their natural function.  These cell clusters can be made from most cell types. Likarda is interested in producing targeted cell therapies beyond its own internal pipeline.

Additionally, to make transplantation and the supply chain more scalable, Likarda is using its proprietary cryopreservation storage technique to create a first-of-its-kind companion animal tissue donation bank.

Microencapsulation
When cells from a donor are transplanted into a recipient’s body without protection, they are attacked by the immune system as being foreign. In order to prevent this attack and protect the cell transplants, standard therapy of systemic immunosuppressive drugs have been administered. In contrast, we microencapsulate (or coat) our cells in a hydrogel material that blocks the immune system from attacking the transplanted cells. At Likarda, we’ve developed and patented a novel process to microencapsulate cells and cell clusters using hydrogels that were once only thought to be usable only in a bulk or large format. These microencapsulated beads, ranging in size from 500-1000 microns, protect the encapsulated cells from the destruction by cells of the immune system while still allowing for small molecules and nutrients (oxygen, glucose, insulin) to freely diffuse and the cells to survive.

 Encapsulated cell clusters

Developing novel cell therapies for pets or humans
At Likarda, we are currently focused on developing novel therapies for pets suffering from endocrine diseases, but we find that this is just the beginning.  Our proprietary technologies (including 3D cell culture and microencapsulation) and our R&D expertise make us a great partner to support the development of your cell-based therapy as well.  Whether it is for animals or humans, our microencapsulation system provides a novel and suitable immunoprotective shield for cell-based treatments of all types.