CSS® Encapsulation for Preclinical and Animal StudiesVersatile. Tunable. Translational.
Likarda’s Core Shell Spherification® (CSS®) platform provides a powerful tool for early-stage drug development—supporting a wide range of preclinical applications across biologics, peptides, small molecules, and cell therapies. Whether you’re exploring PK/PD, dosing frequency, biodistribution, mechanism of action, or immune shielding, CSS® allows you to test encapsulated formulations that mimic final-use scenarios in both in vitro and in vivo settings.
Key Applications
In Vitro Screening
Evaluate cell viability, functionality, and controlled release in a defined, high-throughput environment.
Rodent & Large Animal Studies
Administer microencapsulated therapeutics via subcutaneous or targeted injection to assess safety, efficacy, and pharmacokinetics.
Formulation Optimization
Compare release profiles and stability across multiple hydrogel chemistries and encapsulation parameters.
Cryopreservation Testing
Assess cold chain resilience of encapsulated materials during transport and storage for real-world readiness.
Immunogenicity Models
Use encapsulated allogeneic or xenogeneic cells to evaluate immune protection in relevant animal models.
What Makes CSS® Unique for Preclinical Use?
- Customizable: Tailor loading density, release kinetics, and hydrogel composition to your payload.
- Versatile: Compatible with cells, biologics, peptides, and small molecules.
- Practical: Supports both dry ice and LN2 transport for live or preserved studies.
- Fast: Rapid turnaround for feasibility and small-batch testing.
- Translational: Designs align with scale-up and regulatory planning.
