Supporting the Research Likarda Performs

The publications supporting the research performed at Likarda are listed below. If you are unable to access or read any of the following publications, please contact us and we will assist you with gaining access.

Cell Therapies to Treat Diabetes

Integration of mesenchymal stem cells into islet cell spheroids improves long-term viability, but not islet function.

Rawal S, Williams SJ, Ramachandran K, Stehno-Bittel L.
Islets. 2017 Sep 3;9(5):87-98. doi: 10.1080/19382014.2017.1341455. Epub 2017 Jun 29.

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Long-term cryopreservation of reaggregated pancreatic islets resulting in successful transplantation in rats.

Rawal S, Harrington S, Williams SJ, Ramachandran K, Stehno-Bittel L.
Cryobiology. 2017 Jun;76:41-50. doi: 10.1016/j.cryobiol.2017.04.010. Epub 2017 May 5.

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The Flaws and Future of Islet Volume Measurements.

Huang HH, Harrington S, Stehno-Bittel L.
Cell Transplant. 2018 Jul;27(7):1017-1026. doi: 10.1177/0963689718779898. Epub 2018 Jun 28.

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Improved yield of canine islet isolation from deceased donors.

Harrington S, Williams SJ, Otte V, Barchman S, Jones C, Ramachandran K, Stehno-Bittel L.
BMC Vet Res. 2017 Aug 22;13(1):264. doi: 10.1186/s12917-017-1177-2.

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Reduction of diffusion barriers in isolated rat islets improves survival, but not insulin secretion or transplantation outcome.

Williams SJ, Huang HH, Kover K, Moore W, Berkland C, Singh M, Smirnova IV, MacGregor R, Stehno-Bittel L.
Organogenesis. 2010 Apr-Jun;6(2):115-24.

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Differences in insulin biosynthesis pathway between small and large islets do not correspond to insulin secretion.

Huang HH, Stehno-Bittel L.
Islets. 2015;7(5):e1129097. doi: 10.1080/19382014.2015.1129097.

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A Simple Method to Replace Islet Equivalents for Volume Quantification of Human Islets.

Ramachandran K, Huang HH, Stehno-Bittel L.
Cell Transplant. 2015;24(7):1183-94. doi: 10.3727/096368914X681928. Epub 2014 May 15.

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Small rat islets are superior to large islets in in vitro function and in transplantation outcomes.

MacGregor RR, Williams SJ, Tong PY, Kover K, Moore WV, Stehno-Bittel L.
Am J Physiol Endocrinol Metab. 2006 May;290(5):E771-9. Epub 2005 Nov 22.

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Small human islets comprised of more β-cells with higher insulin content than large islets.

Farhat B, Almelkar A, Ramachandran K, Williams SJ, Huang HH, Zamierowksi D, Novikova L, Stehno-Bittel L.

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Elimination of T cell reactivity to pancreatic β cells and partial preservation of β cell activity by peptide blockade of LFA-1:ICAM-1 interaction in the NOD mouse model.

Dotson AL, Novikova L, Stehno-Bittel L, Benedict SH.
Clin Immunol. 2013 Aug;148(2):149-61. doi: 10.1016/j.clim.2013.04.016. Epub 2013 May 9.

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Expression and regulation of nampt in human islets.

Kover K, Tong PY, Watkins D, Clements M, Stehno-Bittel L, Novikova L, Bittel D, Kibiryeva N, Stuhlsatz J, Yan Y, Ye SQ, Moore WV.
PLoS One. 2013;8(3):e58767. doi: 10.1371/journal.pone.0058767. Epub 2013 Mar 11.

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Diffusion into human islets is limited to molecules below 10 kDa.

Williams SJ, Schwasinger-Schmidt T, Zamierowski D, Stehno-Bittel L.
Tissue Cell. 2012 Oct;44(5):332-41. doi: 10.1016/j.tice.2012.05.001. Epub 2012 Jun 19.

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A replacement for islet equivalents with improved reliability and validity.

Huang HH, Ramachandran K, Stehno-Bittel L.
Acta Diabetol. 2013 Oct;50(5):687-96. doi: 10.1007/s00592-012-0375-4.

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Low insulin content of large islet population is present in situ and in isolated islets.

Huang HH, Novikova L, Williams SJ, Smirnova IV, Stehno-Bittel L.
Islets. 2011 Jan-Feb;3(1):6-13. doi: 10.4161/isl.3.1.14132.

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Drug Screening with 3D Cell Culture and the CC Microplate

Engineering islets for improved performance by optimized reaggregation in a micromold.

Ramachandran K, Williams SJ, Huang HH, Novikova L, Stehno-Bittel L.
Tissue Eng Part A. 2013 Mar;19(5-6):604-12. doi: 10.1089/ten.TEA.2012.0553. Epub 2012 Nov 5.

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A novel three-dimensional stromal-based model for in vitro chemotherapy sensitivity testing of leukemia cells.

Aljitawi OS, Li D, Xiao Y, Zhang D, Ramachandran K, Stehno-Bittel L, Van Veldhuizen P, Lin TL, Kambhampati S, Garimella R.
Leuk Lymphoma. 2014 Feb;55(2):378-91. doi: 10.3109/10428194.2013.793323. Epub 2013 May 15.

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Assessment of re-aggregated human pancreatic islets for secondary drug screening.

Ramachandran K, Peng X, Bokvist K, Stehno-Bittel L.
Br J Pharmacol. 2014 Jun;171(12):3010-22. doi: 10.1111/bph.12622.

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Arum Palaestinum with isovanillin, linolenic acid and β-sitosterol inhibits prostate cancer spheroids and reduces the growth rate of prostate tumors in mice.

Cole C, Burgoyne T, Lee A, Stehno-Bittel L, Zaid G.

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A simple, reliable method for high-throughput screening for diabetes drugs using 3D β-cell spheroids.

Amin J, Ramachandran K, Williams SJ, Lee A, Novikova L, Stehno-Bittel L.
J Pharmacol Toxicol Methods. 2016 Nov – Dec;82:83-89. doi: 10.1016/j.vascn.2016.08.005. Epub 2016 Aug 20.

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An Automated Multiplexed Hepatotoxicity and CYP Induction Assay Using HepaRG Cells in 2D and 3D.

Ott LM, Ramachandran K, Stehno-Bittel L.
SLAS Discov. 2017 Jun;22(5):614-625. doi: 10.1177/2472555217701058. Epub 2017 Mar 27.

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KU-32, a novel drug for diabetic neuropathy, is safe for human islets and improves in vitro insulin secretion and viability.

Farmer K, Williams SJ, Novikova L, Ramachandran K, Rawal S, Blagg BS, Dobrowsky R, Stehno-Bittel L.
Exp Diabetes Res. 2012;2012:671673. doi: 10.1155/2012/671673. Epub 2012 Nov 1.

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Hydrogels for Coating Cells for Transplant

Hyaluronic Acid/Collagen Hydrogel as an Alternative to Alginate for Long-Term Immunoprotected Islet Transplantation

Harrington S, Williams J, Rawal S, Ramachandran K, Stehno-Bittel L.
Tissue Eng Part A. 2017 Oct;23(19-20):1088-1099. doi: 10.1089/ten.TEA.2016.0477. Epub 2017 Mar 2.

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Adhesion of pancreatic beta cells to biopolymer films.

Williams SJ, Wang Q, Macgregor RR, Siahaan TJ, Stehno-Bittel L, Berkland C.
Biopolymers. 2009 Aug;91(8):676-85. doi: 10.1002/bip.21196.

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